C
Fitness & RecoveryStrong Evidence3rd Party Tested

Creatine

Also known as: Creatine Monohydrate, Cr, Phosphocreatine

The most researched performance supplement in existence

9/10 Evidence Score

Primary Benefit

Strength & Power Output

Standard Dose

3–5 g/day

Evidence

Certifications

Informed SportNSF Certified for Sport

Overview

Creatine is a naturally occurring compound found in muscle cells that helps produce energy during high-intensity exercise. As a supplement, creatine monohydrate is one of the most studied and effective ergogenic aids available, with decades of research supporting its safety and efficacy.

Benefits & Evidence

  • Increases high-intensity exercise capacity
  • Supports muscle strength and power gains
  • Accelerates post-exercise recovery
  • May improve cognitive function
  • Supports lean muscle mass gains

Clinical Study Summaries

Creatine supplementation and exercise performance: a brief review

2003

Journal of Sports Science & Medicine

Creatine supplementation significantly improves peak power output and total work during high-intensity exercise.

International Society of Sports Nutrition position stand: creatine supplementation and exercise

2017

Journal of the International Society of Sports Nutrition

Creatine monohydrate is the most effective nutritional supplement for increasing high-intensity exercise capacity and lean body mass.

View study

Recommended Dosage

Standard Dose3–5 g/day
Minimum3 g/day
Maximum5 g/day
TimingPost-workout or any time of day
Notes: Loading phase (20 g/day for 5–7 days) can saturate muscle stores faster but is optional. Creatine monohydrate is the gold-standard form.

Side Effects & Interactions

Potential Side Effects
  • Water retention in muscles (temporary)
  • Minor GI discomfort at high doses
  • Slight weight gain due to water
Drug & Nutrient Interactions
  • Caffeine (may slightly reduce benefits at very high doses)
  • NSAIDs (theoretical renal concern, monitor closely)

Who Should Consider It

Good candidates

  • Athletes seeking improved performance
  • Individuals doing strength or resistance training
  • Older adults looking to preserve muscle mass
  • Vegetarians/vegans with low dietary creatine intake

Use caution or avoid

  • Those with pre-existing kidney disease
  • Check with physician if on diuretics
Medical Disclaimer

This information is for educational purposes only. It does not constitute medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you have health conditions or take medications.

Third-Party Testing

This supplement has products available with independent quality verification.

Informed Sport
NSF Certified for Sport
Evidence Breakdown
Overall Score9/10
Popularity10/10

Evidence Level

Strong

Compare with Similar Supplements